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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>And then what will we die of? <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>Before we make life infinite, we better change the laws to make death voluntary. <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>N<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'><o:p> </o:p></span></p><div><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>Nicholas S. Thompson<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>Emeritus Professor of Psychology and Biology<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'>Clark University<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'><a href="http://home.earthlink.net/~nickthompson/naturaldesigns/"><span style='color:#0563C1'>http://home.earthlink.net/~nickthompson/naturaldesigns/</span></a><o:p></o:p></span></p></div><p class=MsoNormal><span style='font-size:11.0pt;color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #E1E1E1 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:11.0pt'>From:</span></b><span style='font-size:11.0pt'> Friam [mailto:friam-bounces@redfish.com] <b>On Behalf Of </b>Marcus Daniels<br><b>Sent:</b> Friday, September 21, 2018 1:24 AM<br><b>To:</b> The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br><b>Subject:</b> Re: [FRIAM] do animals psychologize?<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:11.0pt'>A couple articles in this week’s Science relating to the programmability of cells.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><a href="http://science.sciencemag.org/content/361/6408/eaap8987">http://science.sciencemag.org/content/361/6408/eaap8987</a><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'>“This enables the design of cycles and developmental networks for engineering applications that require that cells exist in a particular state for an unspecified amount of time. For example, therapeutic cells could be built to sense transient stimuli, such as throughout the gastrointestinal tract, and switch to a new state when the next signal is encountered. There are similar applications for diagnostic cells (<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-48"><i><span style='color:blue'>48</span></i></a>, <a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-76"><i><span style='color:blue'>76</span></i></a>–<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-81"><i><span style='color:blue'>81</span></i></a>), pathways to complex chemicals and materials that require cycles of ordered operations (<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-82"><i><span style='color:blue'>82</span></i></a>), and sentinel plants and microbes with responsive traits (<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-31"><i><span style='color:blue'>31</span></i></a>, <a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-83"><i><span style='color:blue'>83</span></i></a>, <a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-84"><i><span style='color:blue'>84</span></i></a>).”<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><o:p> </o:p></span></p><p class=MsoPlainText><a href="http://science.sciencemag.org/content/361/6408/1252">http://science.sciencemag.org/content/361/6408/1252</a><o:p></o:p></p><p class=MsoPlainText><o:p> </o:p></p><p class=MsoNormal>“<span style='font-size:11.0pt'>For example, existing cancer-detection circuits (<a href="http://science.sciencemag.org/content/361/6408/1252#ref-66"><i><span style='color:blue'>66</span></i></a>, <a href="http://science.sciencemag.org/content/361/6408/1252#ref-67"><i><span style='color:blue'>67</span></i></a>) could conditionally express CHOMP components to increase specificity and couple to protein-mediated inputs and outputs. Integrating these capabilities, one can envision smart therapeutics or sentinels based on CHOMP circuits (<a href="http://science.sciencemag.org/content/361/6408/1252#ref-68"><i><span style='color:blue'>68</span></i></a>, <a href="http://science.sciencemag.org/content/361/6408/1252#ref-69"><i><span style='color:blue'>69</span></i></a>).”<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'>And those are the just some of the friendly applications.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'>Marcus<o:p></o:p></span></p></div></body></html>