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<p class="MsoNormal"><span style="font-size:11.0pt">There’s almost certainly blue-screen-of-death scenarios here – we die of bugs, or bio-malware.
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<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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<p class="MsoNormal"><b><span style="color:black">From: </span></b><span style="color:black">Friam <friam-bounces@redfish.com> on behalf of Nick Thompson <nickthompson@earthlink.net><br>
<b>Reply-To: </b>The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br>
<b>Date: </b>Friday, September 21, 2018 at 8:46 AM<br>
<b>To: </b>'The Friday Morning Applied Complexity Coffee Group' <friam@redfish.com><br>
<b>Subject: </b>Re: [FRIAM] do animals psychologize?<o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D">And then what will we die of?
</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D">Before we make life infinite, we better change the laws to make death voluntary.
</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D">N</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"> </span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D">Nicholas S. Thompson</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D">Emeritus Professor of Psychology and Biology</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D">Clark University</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"><a href="http://home.earthlink.net/~nickthompson/naturaldesigns/">http://home.earthlink.net/~nickthompson/naturaldesigns/</a></span><o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"> </span><o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-size:11.0pt">From:</span></b><span style="font-size:11.0pt"> Friam [mailto:friam-bounces@redfish.com]
<b>On Behalf Of </b>Marcus Daniels<br>
<b>Sent:</b> Friday, September 21, 2018 1:24 AM<br>
<b>To:</b> The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br>
<b>Subject:</b> Re: [FRIAM] do animals psychologize?</span><o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">A couple articles in this week’s Science relating to the programmability of cells.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><a href="http://science.sciencemag.org/content/361/6408/eaap8987">http://science.sciencemag.org/content/361/6408/eaap8987</a></span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">“This enables the design of cycles and developmental networks for engineering applications that require that cells exist in a particular state for an unspecified amount of time. For example, therapeutic cells
could be built to sense transient stimuli, such as throughout the gastrointestinal tract, and switch to a new state when the next signal is encountered. There are similar applications for diagnostic cells (<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-48"><i><span style="color:blue">48</span></i></a>,
<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-76"><i><span style="color:blue">76</span></i></a>–<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-81"><i><span style="color:blue">81</span></i></a>), pathways to complex
chemicals and materials that require cycles of ordered operations (<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-82"><i><span style="color:blue">82</span></i></a>), and sentinel plants and microbes with responsive traits (<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-31"><i><span style="color:blue">31</span></i></a>,
<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-83"><i><span style="color:blue">83</span></i></a>,
<a href="http://science.sciencemag.org/content/361/6408/eaap8987#ref-84"><i><span style="color:blue">84</span></i></a>).”</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoPlainText"><a href="http://science.sciencemag.org/content/361/6408/1252">http://science.sciencemag.org/content/361/6408/1252</a><o:p></o:p></p>
<p class="MsoPlainText"> <o:p></o:p></p>
<p class="MsoNormal">“<span style="font-size:11.0pt">For example, existing cancer-detection circuits (<a href="http://science.sciencemag.org/content/361/6408/1252#ref-66"><i><span style="color:blue">66</span></i></a>,
<a href="http://science.sciencemag.org/content/361/6408/1252#ref-67"><i><span style="color:blue">67</span></i></a>) could conditionally express CHOMP components to increase specificity and couple to protein-mediated inputs and outputs. Integrating these capabilities,
one can envision smart therapeutics or sentinels based on CHOMP circuits (<a href="http://science.sciencemag.org/content/361/6408/1252#ref-68"><i><span style="color:blue">68</span></i></a>,
<a href="http://science.sciencemag.org/content/361/6408/1252#ref-69"><i><span style="color:blue">69</span></i></a>).”</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">And those are the just some of the friendly applications.</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt"> </span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Marcus</span><o:p></o:p></p>
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