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<p class="MsoNormal">From another source (GenBank SRA data) I see several other mutations, A930T, which is in the HR1. This region in part determines how the virus fuses with a cell. They found one nearby at S943P. Here’s some context:<o:p></o:p></p>
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<p class="MsoNormal"> https://www.nature.com/articles/s41422-020-0305-x<o:p></o:p></p>
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<p class="MsoNormal">I see some other mutations in the RBD (receptor binding domain), but they may not be proliferating. I don’t have the breadth of the GISAID data; they are “selective” (cough) about giving it to non-academics. The V483A mutation I also
observed.<o:p></o:p></p>
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<p class="MsoNormal">Marcus<o:p></o:p></p>
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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Friam <friam-bounces@redfish.com> on behalf of Roger Critchlow <rec@elf.org><br>
<b>Reply-To: </b>The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br>
<b>Date: </b>Tuesday, May 5, 2020 at 1:09 PM<br>
<b>To: </b>The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br>
<b>Subject: </b>Re: [FRIAM] Positively selected mutations<o:p></o:p></span></p>
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<p class="MsoNormal">Actually, I should wait and read the whole paper before posting on my phone.
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<p class="MsoNormal">It's not a new new strain, it's the strain of Covid-19 that we've been dealing with on the east coast, a mutant first noticed in Italy in February, but it's been spreading quite successfully through Europe and North America.<o:p></o:p></p>
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<p class="MsoNormal">-- rec --<o:p></o:p></p>
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<p class="MsoNormal">On Tue, May 5, 2020 at 2:49 PM Roger Critchlow <<a href="mailto:rec@elf.org">rec@elf.org</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal">I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup.
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<p class="MsoNormal">-- rec --<o:p></o:p></p>
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<p class="MsoNormal">On Tue, May 5, 2020, 11:47 AM uǝlƃ <span style="font-family:"Apple Color Emoji"">
☣</span> <<a href="mailto:gepropella@gmail.com" target="_blank">gepropella@gmail.com</a>> wrote:<o:p></o:p></p>
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<p class="MsoNormal">Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this
talk of a mutating spike imply something similar will be the case 10 years from now with this one?<br>
<br>
On 5/5/20 3:47 AM, David Eric Smith wrote:<br>
> Have you guys seen this one:<br>
> <br>
> <a href="https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1" target="_blank">
https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1</a><br>
> <br>
> From Tanmoy Bhattacharya et al. Does not look like good news.<br>
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-- <br>
<span style="font-family:"Apple Color Emoji"">☣</span> uǝlƃ<br>
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