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<div style="font-family:sans-serif"><div style="white-space:normal"><p dir="auto">Hmmmmm…… ok</p>
<p dir="auto">On 25 Jan 2021, at 11:59, Marcus Daniels wrote:</p>
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<p style='font-family:"Calibri", sans-serif; font-size:11pt; margin:0'>I think a lot of that could be sorted out from population-based statistical inference from whole genome sequencing and large biobanks.
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<p style='font-family:"Calibri", sans-serif; font-size:11pt; margin:0'><b>From:</b> Friam <friam-bounces@redfish.com> <b>On Behalf Of
</b>Barry MacKichan<br>
<b>Sent:</b> Monday, January 25, 2021 8:09 AM<br>
<b>To:</b> The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br>
<b>Subject:</b> Re: [FRIAM] tangent from uncanny valley</p>
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<p><span style='font-family:"Arial",sans-serif'>There used to be a lot of talk about “junk DNA” which doesn’t do anything, but I’ve gotten the impression (sorry, I can’t give references) that more recently the “junk DNA” does play a role.</span></p>
<p><span style='font-family:"Arial",sans-serif'>Also, adjacency or propinquity of genes on a chromosome affects evolution (if I get one of the genes from a parent, I’m highly likely to get the other also). I have no idea if it plays a role during the life of
a cell. I don’t know anything about how sexual reproduction goes about building a new chromosome by selecting pieces from the chromosomes of the parents, but on the face of it, changing the layout (or in mathematical terms, the metric) could lead to omission
or duplication errors in the result.</span></p>
<p><span style='font-family:"Arial",sans-serif'>TL;DR Be careful what you wish for.</span></p>
<p><span style='font-family:"Arial",sans-serif'>—Barry</span></p>
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<p><span style='font-family:"Arial",sans-serif'>On 22 Jan 2021, at 18:37, Marcus Daniels wrote:</span></p>
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<p><span style='font-family:"Arial",sans-serif;color:#777777'>Most of the human genome doesn't express as proteins, so there should be lots of room to store stuff.<br>
Such technology is hardly science fiction, it's even FDA approved!<br>
<br>
<a href="https://www.fda.gov/news-events/press-announcements/fda-approves-novel-gene-therapy-treat-patients-rare-form-inherited-vision-loss"><span style="color:#777777">https://www.fda.gov/news-events/press-announcements/fda-approves-novel-gene-therapy-treat-patients-rare-form-inherited-vision-loss</span></a><br>
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-----Original Message-----<br>
From: Friam <<a href="mailto:friam-bounces@redfish.com">friam-bounces@redfish.com</a>> On Behalf Of Prof David West<br>
Sent: Friday, January 22, 2021 2:43 PM<br>
To: <a href="mailto:friam@redfish.com">friam@redfish.com</a><br>
Subject: [FRIAM] tangent from uncanny valley<br>
<br>
The idea of posthuman came up (yes it was me) in another thread. This article <a href="https://www.nature.com/articles/s41589-020-00711-4">
<span style="color:#777777">https://www.nature.com/articles/s41589-020-00711-4</span></a> opens an interesting door: "reprogramming" DNA by inserting new data into living DNA. After all a program is just another form of data. This might be orthogonal to genetic
(re)engineering.<br>
<br>
davew<br>
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