<div dir="auto">Did you read the article about aborting babies with Down Syndrome?<br><br><div data-smartmail="gmail_signature">---<br>Frank C. Wimberly<br>140 Calle Ojo Feliz, <br>Santa Fe, NM 87505<br><br>505 670-9918<br>Santa Fe, NM</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Thu, Sep 9, 2021, 6:00 PM ⛧ glen <<a href="mailto:gepropella@gmail.com">gepropella@gmail.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Apples can be red. ... Wait what? What were we talking about? "I have no idea what's goin' on."<br>
<br>
On September 9, 2021 4:54:42 PM PDT, Marcus Daniels <<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a>> wrote:<br>
>Puppies are adorable.<br>
><br>
>From: Friam <<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a>> On Behalf Of Frank Wimberly<br>
>Sent: Thursday, September 9, 2021 4:33 PM<br>
>To: The Friday Morning Applied Complexity Coffee Group <<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a>><br>
>Subject: Re: [FRIAM] gen'fur<br>
><br>
>Down's babies are adorable.<br>
>---<br>
>Frank C. Wimberly<br>
>140 Calle Ojo Feliz,<br>
>Santa Fe, NM 87505<br>
><br>
>505 670-9918<br>
>Santa Fe, NM<br>
><br>
>On Thu, Sep 9, 2021, 3:32 PM Marcus Daniels <<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a><mailto:<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a>>> wrote:<br>
>Or they are reprogramming their people to be smarter!<br>
>(Actually, deCODE is owned by Amgen now.)<br>
><br>
>Selection is already occurring, so it isn't as if this is some sci-fi thing.<br>
><br>
><a href="https://www.theatlantic.com/magazine/archive/2020/12/the-last-children-of-down-syndrome/616928/" rel="noreferrer noreferrer" target="_blank">https://www.theatlantic.com/magazine/archive/2020/12/the-last-children-of-down-syndrome/616928/</a><br>
>-----Original Message-----<br>
>From: Friam <<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a><mailto:<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a>>> On Behalf Of David Eric Smith<br>
>Sent: Thursday, September 9, 2021 2:12 PM<br>
>To: The Friday Morning Applied Complexity Coffee Group <<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a><mailto:<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a>>><br>
>Subject: Re: [FRIAM] gen'fur<br>
><br>
>Aha!  This is why Iceland has the highest per-capita fraction of published authors in the world.  I had assumed it was the weather….<br>
><br>
>> On Sep 10, 2021, at 2:17 AM, Marcus Daniels <<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a><mailto:<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a>>> wrote:<br>
>><br>
>> That can be screened as well with a large population-wide survey such has been done in the UK or Iceland.<br>
>> Of course, it is unlikely that complex behaviors will be governed by isolated mutations, so the task is to look for highly predictive motifs (e.g. regular expressions).<br>
>><br>
>> -----Original Message-----<br>
>> From: Friam <<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a><mailto:<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a>>> On Behalf Of u?l? ?>$<br>
>> Sent: Thursday, September 9, 2021 10:12 AM<br>
>> To: <a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a><mailto:<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a>><br>
>> Subject: Re: [FRIAM] gen'fur<br>
>><br>
>> Ha! Now you're trolling. The answer is: "because the sites that generate reading ability (or whatever) *also* generate other 'abilities'", with "abilities" in scare quotes because many abilities are considered bad ... like the ability of a pimply faced white dude to shoot up a church or blow up a federal building.<br>
>><br>
>> In addition to polyphenism, there's robustness. If more than 1 site generates the same functional ability (reading), then do we write them all? ... just one of them? ... a probabilistically predictive handful of them?<br>
>><br>
>> On 9/9/21 10:00 AM, Marcus Daniels wrote:<br>
>>> So find the sites that correspond to reading ability, or whatever, and WRITE them.<br>
>>><br>
>>> -----Original Message-----<br>
>>> From: Friam <<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a><mailto:<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a>>> On Behalf Of u?l? ?>$<br>
>>> Sent: Thursday, September 9, 2021 9:51 AM<br>
>>> To: <a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a><mailto:<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a>><br>
>>> Subject: Re: [FRIAM] gen'fur<br>
>>><br>
>>> I was alerted to this article this morning:<br>
>>><br>
>>> Can Progressives Be Convinced That Genetics Matters?<br>
>>> <a href="https://www.newyorker.com/magazine/2021/09/13/can-progressives-be-con" rel="noreferrer noreferrer" target="_blank">https://www.newyorker.com/magazine/2021/09/13/can-progressives-be-con</a><br>
>>> v<br>
>>> inced-that-genetics-matters<br>
>>><br>
>>> It should delight those amongst us who rant about the "woke". 8^D But it dovetails nicely with the fraught concept of equality in the other thread.<br>
>>><br>
>>> Coincidentally, also on 9/6, the BIAPT announced their early career prize winner Emily McTernan:<br>
>>> <a href="https://linkprotect.cudasvc.com/url?a=https%3a%2f%2fwww.associationfo" rel="noreferrer noreferrer" target="_blank">https://linkprotect.cudasvc.com/url?a=https%3a%2f%2fwww.associationfo</a><br>
>>> <a href="http://rpoliticalthought.ac.uk" rel="noreferrer noreferrer" target="_blank">rpoliticalthought.ac.uk</a><<a href="http://rpoliticalthought.ac.uk" rel="noreferrer noreferrer" target="_blank">http://rpoliticalthought.ac.uk</a>>%2fbiapt-2021-early-care&c=E,1,Je9MVNdO8lpJQOd<br>
>>> 6fZwUNe-4z5yuFq0upxNIzMBFjmLFh_h5a63ueVVpd8lkEdWeUx5Xx1RaoPg3T5Ph8YlG<br>
>>> 0558qqHLZD8-DKeBPEC3YYM,&typo=1<br>
>>> er-prize-winner-dr-emily-mcternan/<br>
>>><br>
>>> "In her forthcoming monograph, Dr McTernan develops her work on social equality further, to advance a pioneering conceptual account – and robust normative defence – of the phenomenon of ‘taking offence’. Therein, McTernan contends, we should understand taking offence, under appropriate conditions, as a civic virtue rather than a vice, as an emotion that embodies the resistance of social inequalities within a community."<br>
>>><br>
>>><br>
>>> On 9/8/21 8:06 PM, Marcus Daniels wrote:<br>
>>>> From about a cancer rate of 10% (without mutation) to 50% (with) but it depends on the BRCA variant.<br>
>>>><br>
>>>> <a href="https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/breast_ca" rel="noreferrer noreferrer" target="_blank">https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/breast_ca</a><br>
>>>> n<br>
>>>> c<br>
>>>> er.htm<br>
>>>> <<a href="https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/breast_c" rel="noreferrer noreferrer" target="_blank">https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/breast_c</a><br>
>>>> a<br>
>>>> n<br>
>>>> cer.htm><br>
>>>><br>
>>>>> On Sep 8, 2021, at 4:07 PM, Frank Wimberly <<a href="mailto:wimberly3@gmail.com" target="_blank" rel="noreferrer">wimberly3@gmail.com</a><mailto:<a href="mailto:wimberly3@gmail.com" target="_blank" rel="noreferrer">wimberly3@gmail.com</a>>> wrote:<br>
>>>>><br>
>>>>> <br>
>>>>> Is the Braca gene that little correlated with breast cancer?<br>
>>>>><br>
>>>>> ---<br>
>>>>> Frank C. Wimberly<br>
>>>>> 140 Calle Ojo Feliz,<br>
>>>>> Santa Fe, NM 87505<br>
>>>>><br>
>>>>> 505 670-9918<br>
>>>>> Santa Fe, NM<br>
>>>>><br>
>>>>> On Wed, Sep 8, 2021, 4:57 PM Marcus Daniels <<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a><mailto:<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a>> <mailto:<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a><mailto:<a href="mailto:marcus@snoutfarm.com" target="_blank" rel="noreferrer">marcus@snoutfarm.com</a>>>> wrote:<br>
>>>>><br>
>>>>>    Yeah, it is hard to get excited about “unusual” variance. Modern<br>
>>>>> classification algorithms like gradient boosting make it possible<br>
>>>>> to predict phenotypes, and to me that is a lot more interesting<br>
>>>>> (and still possible to deconstruct).____<br>
>>>>><br>
>>>>>    __ __<br>
>>>>><br>
>>>>>    *From:* Friam <<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a><mailto:<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a>> <mailto:<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a><mailto:<a href="mailto:friam-bounces@redfish.com" target="_blank" rel="noreferrer">friam-bounces@redfish.com</a>>>> *On Behalf Of *Eric Charles<br>
>>>>>    *Sent:* Wednesday, September 8, 2021 3:53 PM<br>
>>>>>    *To:* The Friday Morning Applied Complexity Coffee Group <<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a><mailto:<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a>> <mailto:<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a><mailto:<a href="mailto:friam@redfish.com" target="_blank" rel="noreferrer">friam@redfish.com</a>>>><br>
>>>>>    *Subject:* [FRIAM] gen'fur____<br>
>>>>><br>
>>>>>    __ __<br>
>>>>><br>
>>>>>    Gen'fur this, gen'fur that... and also the realities of biological complexity....<br>
>>>>>    ____<br>
>><br>
>><br>
>> --<br>
>> ☤>$ <br>
-- <br>
glen ⛧<br>
<br>
- .... . -..-. . -. -.. -..-. .. ... -..-. .... . .-. .<br>
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</blockquote></div>