<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">Again thank you.<div><br></div><div>The result is over-interpreted, but I’m glad to have it, and it is related to the way I want to frame some of these questions.</div><div><br></div><div>Donna is defnly one of the silverbacks. She is the one who did the solution-separation experiments I referred to in the last post. It is good to know she did as much as this. It suggests that the elementary synthesis kinetics — in the system they built — favor doing exactly the _wrong_ thing that goes nowhere. </div><div><br></div><div>People are really dug into the Central Dogma picture of control flow, because they think that gives them Darwin. So they must “synthesize first; then fold”. But I think that in the long run, that will not be the framing that gets at the contextually-relevant causal explanations.</div><div><br></div><div>Still, great; good to have in the toolbox.</div><div><br></div><div>Eric</div><div><br></div><div><br></div><div><br id="lineBreakAtBeginningOfMessage"><div><br><blockquote type="cite"><div>On Jan 30, 2025, at 11:54, Sarbajit Roy <sroy.mb@gmail.com> wrote:</div><br class="Apple-interchange-newline"><div><div dir="ltr"><div class="gmail_default" style="font-family:verdana,sans-serif"><br>"<span style="color:rgb(17,17,17);font-family:Roboto,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,"Helvetica Neue",Arial,"Noto Sans",sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";font-size:18px">The researchers specifically sought to reproduce homochirality in a central process in amino acid production called transamination, by using a relatively simple, plausibly prebiotic chemistry that excludes complex enzymes.</span></div><p style="box-sizing:border-box;margin-top:0px;margin-bottom:1.66667em;color:rgb(17,17,17);font-family:Roboto,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,"Helvetica Neue",Arial,"Noto Sans",sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";font-size:18px">In early tests, the team’s experimental reaction worked, and yielded amino acids that were enriched for one chiral form versus the other. The problem was that the favored form was the right-handed form—the one that biology doesn’t use.</p><p style="box-sizing:border-box;margin-top:0px;margin-bottom:1.66667em;color:rgb(17,17,17);font-family:Roboto,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,"Helvetica Neue",Arial,"Noto Sans",sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";font-size:18px">“We were stuck for a while, but then the light bulb went on—we realized we could do part of the reaction in reverse,” Blackmond says.</p><div class="gmail_default" style="font-family:verdana,sans-serif"><span style="color:rgb(17,17,17);font-family:Roboto,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,"Helvetica Neue",Arial,"Noto Sans",sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";font-size:18px">When they did that, the reaction no longer preferentially made right-handed amino acids. In a striking example of kinetic resolution, it instead preferentially consumed and depleted the right-handed versions—leaving more of the desired left-handed amino acids. It thus served as a plausible route to homochirality for amino acids used in living cells.</span>"<br><br><a href="https://linkprotect.cudasvc.com/url?a=https%3a%2f%2fastrobiology.com%2f2024%2f03%2fhow-molecular-handedness-emerged-in-early-biology.html&c=E,1,ucHCjA95g5YAHl1cW2L6IdRV6ALGITq5DTVYkoT0G-Hx_aBzvS7vzcqz5SFSxiy9r6TWvogFNqUSoHYlsnctBrnv5tJDzUWJseAcBUMLk365y3NJ&typo=1">https://astrobiology.com/2024/03/how-molecular-handedness-emerged-in-early-biology.html</a><br><br><a href="https://linkprotect.cudasvc.com/url?a=https%3a%2f%2fwww.pnas.org%2fdoi%2fepdf%2f10.1073%2fpnas.2315447121&c=E,1,klE6LOB5u1cgc8WlOiduCsL9ecTQbALpVUGZyva-aWRBcvdHgF0eKphyYeg5E0RM3N0jh4vCCOJvlsyCs6cwGtwXLSiG16VXg90ZF-sP&typo=1">https://www.pnas.org/doi/epdf/10.1073/pnas.2315447121</a><br></div></div><br><div class="gmail_quote gmail_quote_container"><div dir="ltr" class="gmail_attr">On Thu, Jan 30, 2025 at 8:48 PM glen <<a href="mailto:gepropella@gmail.com">gepropella@gmail.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex"><br>
Asteroid fragments upend theory of how life on Earth bloomed<br>
<a href="https://www.nature.com/articles/d41586-025-00264-3" rel="noreferrer" target="_blank">https://www.nature.com/articles/d41586-025-00264-3</a><br>
"Glavin is most perplexed by the discovery of an equal mixture of left-handed and right-handed amino acids on Bennu. He, like many scientists, had thought that organic molecules from primordial asteroids would have had the same left-handed dominance as those from life on Earth. Now, researchers have to go back to the drawing board to understand how life might have been seeded on Earth."<br>
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I remember but now can't find a recent article about how dangerous right-handed molecules are to life on earth. Peter Ward's book gifted me some rhetoric for a basic belief I'd held for awhile. Renee' believes in (complex) extraterrestrials. I don't, at least within some observation window (i.e. maybe they're out there but we'll never meet them). But it's completely reasonable that life emerged all over the universe. It's just difficult for me to imagine it (life) jumping through all these gen-phen ratchets.<br>
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There must be a sci-fi novel out there where some cluster (alive or not) of right-handed molecules lands on earth and eats away at the biosphere. I can see 2 basic outcomes: 1. death or 2. chirality co-evolution (including where 1 or the other wins out in the "end").<br>
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