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--></style></head><body lang=EN-US link="#0563C1" vlink="#954F72" style='word-wrap:break-word'><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt'>Now that there is Alphafold, perhaps one could use the ribosome to build scaffolding for 3-d semiconductors? That would be another ten-fold reduction in feature size compared to lithography.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt'><o:p> </o:p></span></p><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal style='margin-bottom:12.0pt'><b><span style='font-size:12.0pt;color:black'>From: </span></b><span style='font-size:12.0pt;color:black'>Friam <friam-bounces@redfish.com> on behalf of Jon Zingale <jonzingale@gmail.com><br><b>Date: </b>Tuesday, February 25, 2025 at 1:34 PM<br><b>To: </b>The Friday Morning Applied Complexity Coffee Group <friam@redfish.com><br><b>Subject: </b>Re: [FRIAM] free will<o:p></o:p></span></p></div><div><div><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Verdana",sans-serif;color:#333333'>"</span><span style='font-size:12.0pt;color:black'></span><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'>What is special, if anything, about organisms that have nervous systems built on organic chemistry that could enable something else?"</span><span style='font-size:12.0pt;font-family:"Verdana",sans-serif;color:#333333'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Verdana",sans-serif;color:#333333'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'>For the most part, I agree with you. Why shouldn't there be silicon architectures that get arbitrarily close to the agential quality exhibited by life. On the other hand, I do not yet see anything designed by us that comes close to the complex sophistication of life at the finest scales. In part this seems like a design problem in that we design our chips to function in exact and narrow ways. We engineer against exaptation, much less do we design for anything like Levin style polycomputing. As far as I can tell, nothing in chemistry is solely a camera, microphone, or chemical sensor. The usefulness of molecules in given contexts determine function. This matters to me exactly because enumerating/coding the affordances via modern techniques would almost certainly lead to an explosion in computational complexity, monstrous scaling mismatches or worse. I suspect that the computing architectures we have already found, while impressive and hard won, are still far from what we would need to do meaningful massive multi-channel and heterogeneous information processing at the density we see in life.</span><span style='font-size:12.0pt;font-family:"Verdana",sans-serif;color:#333333'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Verdana",sans-serif;color:#333333'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:12.0pt;font-family:"Arial",sans-serif;color:black'>This is all to say, I doubt we do anything particularly "special", but I would bet that the sun will burn out long before we have agential computers as interesting as life. Regarding free will, I have nothing new to say that we haven't already hashed many times before.</span><span style='font-size:12.0pt;font-family:"Verdana",sans-serif;color:#333333'><o:p></o:p></span></p></div></div></div></body></html>