[FRIAM] Endothelial cell infection and endotheliitis in COVID-19
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gepropella at gmail.com
Mon Jun 1 18:22:15 EDT 2020
Endothelial cell infection and endotheliitis in COVID-19
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext
> Although the virus uses ACE2 receptor expressed by pneumocytes in the epithelial alveolar lining to infect the host, thereby causing lung injury, the ACE2 receptor is also widely expressed on endothelial cells, which traverse multiple organs.3
> Recruitment of immune cells, either by direct viral infection of the endothelium or immune-mediated, can result in widespread endothelial dysfunction associated with apoptosis (figure D).
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