[FRIAM] Manifold Enthusiasts

[Frank Wimberly]

Pregabalin reduces neuronal calcium currents by binding to the α2δ subunit
of calcium channels, and this particular mechanism may be responsible for
effects in *neuropathic pain*, anxiety, and other *pain*syndromes. The
exact mechanism of analgesic effect for *gabapentin* has not been defined.

Duloxetine inhibits the reuptake of serotonin and norepinephrine (NE) in
the central nervous system. Duloxetine increases dopamine (DA) specifically
in the prefrontal cortex, where there are few DA reuptake pumps, via the
inhibition of NE reuptake pumps (NET), which is believed to mediate
reuptake of DA and NE.[53]
<https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-53> Duloxetine has no
significant affinity for dopaminergic, cholinergic, histaminergic, opioid,
glutamate, and GABA reuptake transporters, however, and can therefore be
considered to be a selective reuptake inhibitor at the 5-HT and NE
transporters. Duloxetine undergoes extensive metabolism
<https://en.m.wikipedia.org/wiki/Metabolism>, but the major circulating
metabolites do not contribute significantly to the pharmacologic activity.
[54] <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-54>[55
<https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-Bymaster_2005-55>

-----------------------------------
Frank Wimberly

My memoir:
https://www.amazon.com/author/frankwimberly

My scientific publications:
https://www.researchgate.net/profile/Frank_Wimberly2

Phone (505) 670-9918

On Mon, Mar 11, 2019, 11:57 AM Steven A Smith <sasmyth at swcp.com> wrote:

> Frank -
> > Perhaps annoying clarification.  The word closure has two important
> > meanings.
> >
> > In a topological space a set is closed if it is the complement of an
> > open set.
> >
> > In the more concrete case of Rn, which we're talking about, a set is
> > closed if it contains it's limit points (boundary).
> >
> > The other use of closure is the one Glen(?) mentioned.  The sum of two
> > elements in the set is in the set and the same for other operations.
> >
> > Barry, help!
>
> Yet more good elaboration/correction.  I think for Nick's benefit, the
> second one is *most* relevant, comes closest to your own original
> common-sense idea of "walking around on a surface without falling off"?
> Cannot 2 be derived from 3 with the right assumptions?
>
> Also, I hope your nerve pain is subsiding...  I guess this bodes poorly
> for your tennis game?  At least overhead slams and solid serves, unless
> it is your off-hand that is afflicted?
>
> I'm unfamiliar with the pain meds you mentioned (really all outside of
> the basic salisylic acid, acetomenophen, and ibuprofen.   I was hoping
> your report of the two med's efficacy would lead to some elaboration on
> the question of change of behaviour without change of brain state?
> Where do these meds act?  In the brain tissue itself?  On the pinched
> nerve?  Somewhere in between?   And does that just beg the question over
> into whether the spinal chord and the entire nervous system are
> nominally "part of the brain"?
>
> - Steve
>
>
>
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