[FRIAM] Manifold Enthusiasts

[Frank Wimberly]

Some people have suggested I meditate with the goal of perceiving the pain
as being separate from me.  Or something like that.

The Duloxetine (Cymbalta) has certainly changed my behavior.  I am much
more patient, considerate, loving, empathic, etc.  Some might think I am
more like the ideals of Abrahamic faith traditions which raises the
question of whether you can be a better person by using meds.

Frank

-----------------------------------
Frank Wimberly

My memoir:
https://www.amazon.com/author/frankwimberly

My scientific publications:
https://www.researchgate.net/profile/Frank_Wimberly2

Phone (505) 670-9918

On Mon, Mar 11, 2019, 12:08 PM Frank Wimberly <wimberly3 at gmail.com> wrote:

> Pregabalin reduces neuronal calcium currents by binding to the α2δ
> subunit of calcium channels, and this particular mechanism may be
> responsible for effects in *neuropathic pain*, anxiety, and other *pain*syndromes.
> The exact mechanism of analgesic effect for *gabapentin* has not been
> defined.
>
> Duloxetine inhibits the reuptake of serotonin and norepinephrine (NE) in
> the central nervous system. Duloxetine increases dopamine (DA) specifically
> in the prefrontal cortex, where there are few DA reuptake pumps, via the
> inhibition of NE reuptake pumps (NET), which is believed to mediate
> reuptake of DA and NE.[53]
> <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-53> Duloxetine has
> no significant affinity for dopaminergic, cholinergic, histaminergic,
> opioid, glutamate, and GABA reuptake transporters, however, and can
> therefore be considered to be a selective reuptake inhibitor at the 5-HT
> and NE transporters. Duloxetine undergoes extensive metabolism
> <https://en.m.wikipedia.org/wiki/Metabolism>, but the major circulating
> metabolites do not contribute significantly to the pharmacologic activity.
> [54] <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-54>[55
> <https://en.m.wikipedia.org/wiki/Duloxetine#cite_note-Bymaster_2005-55>
>
> -----------------------------------
> Frank Wimberly
>
> My memoir:
> https://www.amazon.com/author/frankwimberly
>
> My scientific publications:
> https://www.researchgate.net/profile/Frank_Wimberly2
>
> Phone (505) 670-9918
>
> On Mon, Mar 11, 2019, 11:57 AM Steven A Smith <sasmyth at swcp.com> wrote:
>
>> Frank -
>> > Perhaps annoying clarification.  The word closure has two important
>> > meanings.
>> >
>> > In a topological space a set is closed if it is the complement of an
>> > open set.
>> >
>> > In the more concrete case of Rn, which we're talking about, a set is
>> > closed if it contains it's limit points (boundary).
>> >
>> > The other use of closure is the one Glen(?) mentioned.  The sum of two
>> > elements in the set is in the set and the same for other operations.
>> >
>> > Barry, help!
>>
>> Yet more good elaboration/correction.  I think for Nick's benefit, the
>> second one is *most* relevant, comes closest to your own original
>> common-sense idea of "walking around on a surface without falling off"?
>> Cannot 2 be derived from 3 with the right assumptions?
>>
>> Also, I hope your nerve pain is subsiding...  I guess this bodes poorly
>> for your tennis game?  At least overhead slams and solid serves, unless
>> it is your off-hand that is afflicted?
>>
>> I'm unfamiliar with the pain meds you mentioned (really all outside of
>> the basic salisylic acid, acetomenophen, and ibuprofen.   I was hoping
>> your report of the two med's efficacy would lead to some elaboration on
>> the question of change of behaviour without change of brain state?
>> Where do these meds act?  In the brain tissue itself?  On the pinched
>> nerve?  Somewhere in between?   And does that just beg the question over
>> into whether the spinal chord and the entire nervous system are
>> nominally "part of the brain"?
>>
>> - Steve
>>
>>
>>
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>
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