[FRIAM] Positively selected mutations

[Marcus Daniels]

From another source (GenBank SRA data) I see several other mutations, A930T, which is in the HR1.   This region in part determines how the virus fuses with a cell.    They found one nearby at S943P.    Here’s some context:

   https://www.nature.com/articles/s41422-020-0305-x

I see some other mutations in the RBD (receptor binding domain), but they may not be proliferating.    I don’t have the breadth of the GISAID data; they are “selective” (cough) about giving it to non-academics.   The V483A mutation I also observed.

Marcus

From: Friam <friam-bounces at redfish.com> on behalf of Roger Critchlow <rec at elf.org>
Reply-To: The Friday Morning Applied Complexity Coffee Group <friam at redfish.com>
Date: Tuesday, May 5, 2020 at 1:09 PM
To: The Friday Morning Applied Complexity Coffee Group <friam at redfish.com>
Subject: Re: [FRIAM] Positively selected mutations

Actually, I should wait and read the whole paper before posting on my phone.

It's not a new new strain, it's the strain of Covid-19 that we've been dealing with on the east coast, a mutant first noticed in Italy in February, but it's been spreading quite successfully through Europe and North America.

-- rec --

On Tue, May 5, 2020 at 2:49 PM Roger Critchlow <rec at elf.org<mailto:rec at elf.org>> wrote:
I think the implication is that there is a wave of more infectious covid building right now, just when everyone was looking for a chance to catch their breathand regroup.

-- rec --


On Tue, May 5, 2020, 11:47 AM uǝlƃ ☣ <gepropella at gmail.com<mailto:gepropella at gmail.com>> wrote:
Thanks! So, is the implication that even after we get some one vaccine, it may not be very effective? Like the flu. The flu shot Renee' gets at the hospital include 4 strains, whereas the ones I get at my clinic have only 3. So, does this talk of a mutating spike imply something similar will be the case 10 years from now with this one?

On 5/5/20 3:47 AM, David Eric Smith wrote:
> Have you guys seen this one:
>
> https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1
>
> From Tanmoy Bhattacharya et al.  Does not look like good news.


--
☣ uǝlƃ

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