[FRIAM] gen'fur

Fri Sep 10 09:30:05 EDT 2021

Guidance could have been to first vaccinate younger adults rather than older adults?   That statistical regularity is predictive of infection and of death.   Other statistical regularities are just correlations and the causality is not clear.   Are you saying there is something special about genotype/phenotype relations?  

> On Sep 10, 2021, at 3:26 AM, ⛧ glen <gepropella at gmail.com> wrote:
> 
> I can't help but wonder if there's an analog of Goodhart's law lurking, here.
> 
> 
>> On September 9, 2021 2:31:39 PM PDT, Marcus Daniels <marcus at snoutfarm.com> wrote:
>> Or they are reprogramming their people to be smarter!
>> (Actually, deCODE is owned by Amgen now.)
>> 
>> Selection is already occurring, so it isn't as if this is some sci-fi thing.
>> 
>> https://www.theatlantic.com/magazine/archive/2020/12/the-last-children-of-down-syndrome/616928/
>> -----Original Message-----
>> From: Friam <friam-bounces at redfish.com> On Behalf Of David Eric Smith
>> Sent: Thursday, September 9, 2021 2:12 PM
>> To: The Friday Morning Applied Complexity Coffee Group <friam at redfish.com>
>> Subject: Re: [FRIAM] gen'fur
>> 
>> Aha!  This is why Iceland has the highest per-capita fraction of published authors in the world.  I had assumed it was the weather….
>> 
>>>> On Sep 10, 2021, at 2:17 AM, Marcus Daniels <marcus at snoutfarm.com> wrote:
>>> 
>>> That can be screened as well with a large population-wide survey such has been done in the UK or Iceland.
>>> Of course, it is unlikely that complex behaviors will be governed by isolated mutations, so the task is to look for highly predictive motifs (e.g. regular expressions).  
>>> 
>>> -----Original Message-----
>>> From: Friam <friam-bounces at redfish.com> On Behalf Of u?l? ?>$
>>> Sent: Thursday, September 9, 2021 10:12 AM
>>> To: friam at redfish.com
>>> Subject: Re: [FRIAM] gen'fur
>>> 
>>> Ha! Now you're trolling. The answer is: "because the sites that generate reading ability (or whatever) *also* generate other 'abilities'", with "abilities" in scare quotes because many abilities are considered bad ... like the ability of a pimply faced white dude to shoot up a church or blow up a federal building.
>>> 
>>> In addition to polyphenism, there's robustness. If more than 1 site generates the same functional ability (reading), then do we write them all? ... just one of them? ... a probabilistically predictive handful of them?
>>> 
>>> On 9/9/21 10:00 AM, Marcus Daniels wrote:
>>>> So find the sites that correspond to reading ability, or whatever, and WRITE them.  
>>>> 
>>>> -----Original Message-----
>>>> From: Friam <friam-bounces at redfish.com> On Behalf Of u?l? ?>$
>>>> Sent: Thursday, September 9, 2021 9:51 AM
>>>> To: friam at redfish.com
>>>> Subject: Re: [FRIAM] gen'fur
>>>> 
>>>> I was alerted to this article this morning:
>>>> 
>>>> Can Progressives Be Convinced That Genetics Matters?
>>>> https://www.newyorker.com/magazine/2021/09/13/can-progressives-be-con
>>>> v
>>>> inced-that-genetics-matters
>>>> 
>>>> It should delight those amongst us who rant about the "woke". 8^D But it dovetails nicely with the fraught concept of equality in the other thread.
>>>> 
>>>> Coincidentally, also on 9/6, the BIAPT announced their early career prize winner Emily McTernan:
>>>> https://linkprotect.cudasvc.com/url?a=https%3a%2f%2fwww.associationfo
>>>> rpoliticalthought.ac.uk%2fbiapt-2021-early-care&c=E,1,Je9MVNdO8lpJQOd
>>>> 6fZwUNe-4z5yuFq0upxNIzMBFjmLFh_h5a63ueVVpd8lkEdWeUx5Xx1RaoPg3T5Ph8YlG
>>>> 0558qqHLZD8-DKeBPEC3YYM,&typo=1
>>>> er-prize-winner-dr-emily-mcternan/
>>>> 
>>>> "In her forthcoming monograph, Dr McTernan develops her work on social equality further, to advance a pioneering conceptual account – and robust normative defence – of the phenomenon of ‘taking offence’. Therein, McTernan contends, we should understand taking offence, under appropriate conditions, as a civic virtue rather than a vice, as an emotion that embodies the resistance of social inequalities within a community."
>>>> 
>>>> 
>>>> On 9/8/21 8:06 PM, Marcus Daniels wrote:
>>>>> From about a cancer rate of 10% (without mutation) to 50% (with) but it depends on the BRCA variant.
>>>>> 
>>>>> https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/breast_ca
>>>>> n
>>>>> c
>>>>> er.htm
>>>>> <https://www.cdc.gov/genomics/disease/breast_ovarian_cancer/breast_c
>>>>> a
>>>>> n
>>>>> cer.htm>
>>>>> 
>>>>>> On Sep 8, 2021, at 4:07 PM, Frank Wimberly <wimberly3 at gmail.com> wrote:
>>>>>> 
>>>>>> 
>>>>>> Is the Braca gene that little correlated with breast cancer?
>>>>>> 
>>>>>> ---
>>>>>> Frank C. Wimberly
>>>>>> 140 Calle Ojo Feliz,
>>>>>> Santa Fe, NM 87505
>>>>>> 
>>>>>> 505 670-9918
>>>>>> Santa Fe, NM
>>>>>> 
>>>>>> On Wed, Sep 8, 2021, 4:57 PM Marcus Daniels <marcus at snoutfarm.com <mailto:marcus at snoutfarm.com>> wrote:
>>>>>> 
>>>>>>   Yeah, it is hard to get excited about “unusual” variance. Modern 
>>>>>> classification algorithms like gradient boosting make it possible 
>>>>>> to predict phenotypes, and to me that is a lot more interesting 
>>>>>> (and still possible to deconstruct).____
>>>>>> 
>>>>>>   __ __
>>>>>> 
>>>>>>   *From:* Friam <friam-bounces at redfish.com <mailto:friam-bounces at redfish.com>> *On Behalf Of *Eric Charles
>>>>>>   *Sent:* Wednesday, September 8, 2021 3:53 PM
>>>>>>   *To:* The Friday Morning Applied Complexity Coffee Group <friam at redfish.com <mailto:friam at redfish.com>>
>>>>>>   *Subject:* [FRIAM] gen'fur____
>>>>>> 
>>>>>>   __ __
>>>>>> 
>>>>>>   Gen'fur this, gen'fur that... and also the realities of biological complexity.... 
>>>>>>   ____
>>> 
> 
> -- 
> glen ⛧
> 
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