[FRIAM] better simulating actual FriAM

Frank Wimberly wimberly3 at gmail.com
Fri Jul 17 19:32:21 EDT 2020


In a project I was working on in the 70s we said that we were trying to
identify phenotypic manifestations of a genetic predisposition to develop
schizophrenia.  Does that work for you?

---
Frank C. Wimberly
140 Calle Ojo Feliz,
Santa Fe, NM 87505

505 670-9918
Santa Fe, NM

On Fri, Jul 17, 2020, 5:27 PM uǝlƃ ↙↙↙ <gepropella at gmail.com> wrote:

> Neither! Ha! As Colleen Green mumbles: "Once you get to know me, you won't
> love me anymore." https://youtu.be/ankOO77de7o
>
> You're both a little wrong and a little right. The gen-phen map is
> inspired by genotype-phenotype. But liberties are taken with what it can
> mean. In particular, I've worked with some clinicians who call any pattern
> they're looking for in their patients a "phenotype". It's a very loose use
> of the word, but it gets the job done for them. For *me*, I tend to mean
> *only* systems where the phenomen[on|a] exert[s] some kind of downward
> causation on the generators (mostly just setting constraints). Maybe I
> should start calling it the phen-gen map instead?
>
> On 7/17/20 4:00 PM, thompnickson2 at gmail.com wrote:
> > At the very end you spoke of the generator/phenomenon distinction.  I
> bet Jon a million dollars that you did NOT mean the same thing as the
> genotype/phenotype distinction.  So.  Who's your friend, here?
>
> --
> ↙↙↙ uǝlƃ
>
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